Effects of poly (ADP-ribose) polymerase inhibitor on early peripheral neuropathy in streptozotocin-diabetic rat
Wei Guo
Chenghong Zheng
Jie Xu
摘要：Objective: To explore the effects and mechanisms of poly (ADP-ribose) polymerase (PARP) inhibitor 3-aminobenzamide on nerve lesions in streptozotocin-diabetic rats. Methods: Experimental rats were divided into normal control group(NC group), diabetic control group (DC group)and diabetic group treated with 3-aminobenzamide (DT group ) .Nerve conduction velocity (NCV),serum superoxide dismutase (SOD) activity and serum malondialdehyde (MDA) concentration,phosphocreatine (Pcr),creatine (Cr) concentration in sciatic nerves were evaluated after 4 weeks. Results: SOD, Pcr activity, and NCV were higher (P ＜ 0.05)and MDA concentration were significantly lower in DT group, compared with DC group (P ＜ 0.01). Meanwhile, ATP and Cr in sciatic nerves were similar in DT group, compare d with DC group (P ＞ 0.05). Conclusion: 3-aminobenzamide could alleviate the established functional and metabolic abnormalities of early DPN in the streptozotocin-induced diabetic rat models,which provided a novel approach for prevention and treatment of diabetic neuropathy.
机标关键词：
分类号：R74(神经病学与精神病学)
论文发表日期：2007-03-02
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 104-107 )
英文信息