Histomorphological observation in arterial remodeling following New Zealand rabbit auto-extremity artery transplantation
Yangyang Zhang
Wen Ge
Biao Yuan
Xiaohu Zhang
Kejiang Cao
摘要：Objective:To investigate the histomorphological change in auto-extremity artery following transplantation.Methods:50 New Zealand rabbits were randomly divided into 5 groups(postoperative 1 d,3 d,7 d,14 d,56 d,n=10).Femoral artery was harvested and end-to-side anastomosed with carotid in order to build the auto-extremity arterial graft animal model.On the postoperative 1st,3rd,7th,14th and 56th days.grafts for morphometric analysis under the Image analysis system were obtained;and electron microscope was scanned to observe endothelial cells.In addition,Immunostaining of sections were performed with the mouse monoclonal antibody of the α-smooth muscle isoform of actin and proliferating cell nuclear antigen antibody.Results:Overall patency rate for all conduits was86%.The intimal hyperplasia was first observed in the 7th day group,and continued to increase in the 56th day group(183.21±111.74)μm,P＜0.01.Additionally,the luminal narrowed(32.43±18.28)%in the 56th day group.Smooth muscle cells were the mainly hyperplastic components.The most active proliferation of cells was detected in the 14th day group.where the extracellular matrix gradually deposited in the intima.Conclusion:Moderate intimal hyperplasia occurred in arterial conduits and vascular structure experienced constrictive remodeling after auto-transplantation.
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分类号：R6(外科学)
论文发表日期：2007-11-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 367-371 )
英文信息