Effects of sodium ferulate on the ultrarapid delayed rectifier K current in human atrial myocytes
Xiang Gao
Kun Liu
Jinping Liu
Yanfu Wang
Changwei Zhang
Zhijian Chen
Qiutang Zeng
Yuhua Liao
摘要：Objective: To study the effects of sodium ferulate on the ultrarapid delayed rectifier K+ current(Ikur) in human atrial myocytes.Methods:Human atrial myocytes were isolated by enzyme dispersion method. Ikur in human atrial myocytes were recorded by using the whole cell patch clamp. The changes of Ikur were compared in the absence and the presence of sodium ferulate. Results:There was no effect of 0.4 g/L sodium ferulate on I-V relation of Ikur However, 0.4 g/L sodium ferulate inhibited Ikur to some degrees at each test pulse. The current densities of Ikur at +60 mV decreased from 4.997 ± 0.35 PA/PF to 3.331 ± 0.26 PA/PF(n = 6, P ＜ 0.05). The inhibitory effect was concentration-dependent. IC50 was(0.41 ± 0.03)g/L and the Hill coefficient was 0.95 ± 0.05. Conclusion:Sodium ferulate as a potassium channel blocker can inhibit Ikur in human atrial myocytes effectively.
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分类号：R3(基础医学)
资助基金：国家自然科学基金(30700747)
论文发表日期：2008-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 1-4 )
英文信息