Research status of the mechanism and treatment for acute pancreatitis complicated with hepatic injury
Xiping Zhang
Jie Zhang
Ping Yang
摘要：Acute pancreatitis(AP) is characterized by its sudden onset and rapid progression and is often complicated by liver injury. AP induced liver injury may develop into hepatic failure and even result in death. Thus, it is of importance to protect liver function and block injury-related pathways. In the pathogenesis of liver injury in AP, inflammatory cytokines, nuclear factor-kappa B(NF- K B) and oxygen free radicals play important roles. The complexity of the mechanism underlying the development of liver injury exerts, to some extent, a contribution to the difficulties in the treatment of this disease. Currently, the drugs used to treat the disease include L-arginine (L-Arg),calcium ion antagonists, somatostatin and a variety of inflammatory mediator inhibitors. Additionally, some traditional Chinese medicines such as tfipterygium, wiifordii, rhubarb and salvia miltiorrhizae may also have some effects. In this article, the pathogenesis of liver injury in AP and its therapy are reviewed.
机标关键词：hepatic injuryliver injurytraditional Chinese medicinesinflammatory mediatoroxygen free radicalshepatic failureliver function
分类号：R6(外科学)
资助基金：technological foundation project of Tradi tional Chinese Medicine Science of Zhejiang. province(2003C130;2004C142)foundation project for medical science and technology of Zhejiang province(2003B134)grave foundation project for technological and development of Hangzhou(2003123B19)intensive foundation project for technology of Hangzhou(2004Z006)foundation project for medical science and technology of Hangzhou(2003A004)foundation project for technology of Hangzhou(2005224)
论文发表日期：2008-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 199-204 )
英文信息