Dipyridamole enhances inhibitory effect of adenosine on neutrophils in human peripheral blood
Yu Zhang
Qingyan Zhang
Jing Zhang
Qian Tian
minghua Li
摘要：Objective:It was known that neutrophils play an important role in ischemic-reperfusion injury. In this study we tested the effect and its mechanism of dipyridamole on neutrophils. Methods:Hydrogen peroxide(H2O2) production by neutrophils was determined using luminol amplified chemiluminescence and the percentage of activity was calculated by observing the uninhibited peak height. Results: Dipyridamole per se produced a concentration-dependent inhibition of H2O2 by formyl-MetleuPhe(fMLP)-stimulated neutrophils. Dipy adenosine on neutrophils. On the other hand, dipyridamole did not alter the inhibitory effect of NECA(5' -N-ethylcarboxamidoadenosine) on neutrophils. However, propentofylline, a known inhibitor of adenosine uptake, also gotten the same result. Conclusion:Dipy fidamole inhibited the production of H202 by fMLP-stimulated neutrophils. Dipyridamole at a low concentration enhanced the inhibi tory effect of adenosine on neutrophils. The mechanism involved is probably due to the effect of dipyridamole on adenosine uptake.
机标关键词：peripheral bloodinhibitory effect
分类号：R3(基础医学)
论文发表日期：2008-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 243-245 )
英文信息