Expression of Survivin, p53 and its relationship with apoptosis, proliferation in hepatocellular carcinoma(HCC)
Wentao Hui
Ying Zan
Xijng Wang
Huafeng kang
Haitao Guan
Xiaobin Ma
摘要：Objective:To investigate the expression of Survivinp53 and its relationship with apoptosis, proliferation in hepatocellular carcinoma (HCC).Methods:The expression of Survivin, p53 and the proliferation of tumor cells marked by proliferation cell nuclear antigen (PCNA) in 42 cases of HCC were assessed by immunohistochemical method.TUNEL was used to detect apoptosis.Results:Survivin protein was expressed in 30 of 42 cases of HCC(71.4%) and in 4 of 34 cases of adjacent cirrhosis tissues(11.8%).Expression of Survivin protein was negative in 10 cases of normal tissues.Survivin protein positive expression rate in HCC was significantly higher than adjacent cirrhosis tissues and normal tissues(P< 0.001).The increased Survivin protein expression in cancer was significantly associ ated with histological grade(P＝ 0.003), p53 protein(P ＝ 0.013), survival time(P < 0.05) and the ratio of proliferative index to apoptotic index(P< 0.01), but was not significantly correlated with age, sex, clinical stage, tumor size, metastasis, AFP, HBs-Ag(P > 0.05).Conclusion:There is a marked increased expression of Survivin in HCC, which may play an important role in breaking the balance of proliferation and apoptosis of HCC cells.The correlation between Survivin and p53 expression in HCC indicates that cooperation between Survivin and p53 plays a certain role in occurrence and/or development of HCC.
机标关键词：Survivin proteinimmunohistochemical methodhepatocellular carcinomaprotein expressiontumor cells
分类号：R73(肿瘤学)
论文发表日期：2008-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 255-259 )
英文信息