Impairments of spatial learning and memory in rat offspring with fetal growth restriction
Pu Huang
Wenli Gou
Mali Jiang
Rui Zhang
Yunping Sun
摘要：Objective:Throughout the world,fetal growth restriction(FGR) is one of the most severe complications occurring during pregnancy.It is subsequently associated with neurologic abnormalities in chldren.Our aim was to investigate the spatial learning and memory ability of rat offspring born with FGR.Methods:A rat model of FGR was constructed using the method of passive smoking.Spatial learning and memory were studied in rat offspring born with FGR by assessing the animals'performance using the Morris water maze task.Results:At 1- and 2- months of age,both female and male offspring rats showed impairment of performance,while at 4 months of age,only female rats showed impaired performance.The FGR offspring spent a longer time swimming and used inefficient strategies(P< 0.05,respectively).However,there were no significant maze performance FGR effects in the 4 month old male rats.in all groups of FGR offspring,irrespective of age or sex,the time spent in the platform quadrant by the rat was significantly less than that in the control group(P< 0.05).Conclusion:The Morris water maze performance decreased in rat offspring born with FGR.It is suggested that FGR can cause impairments of spatial learning and memory in young animals.
机标关键词：learning and memoryperformanceMorris water mazeFGRfemale ratssignificantstrategiesthe world
分类号：R5(内科学)
资助基金：Xi' an Jiaotong University Education Program,Shanxi Province Science and Technology Project(2004K17-G11)国家自然科学基金(30471826)
论文发表日期：2009-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 54-58 )
英文信息