Polymorphisms in XRCC5, XRCC6, XRCC7 genes are involved in DNA double-strand breaks(DSBs) repair associated with the risk of acute myeloid leukemia(AML) in Chinese population
Guoqiang Wang
Shuyu Wang
Qun Shen
Shiwei Yin
Chunping Li
Aiping Li
Jianyong Li
Jianwei Zhou
Qizhan Liu
摘要：Objective:To investigate the association between the X-ray repair cross complementing(XRCC) group 5, XRCC6 and XRCC7 polymorphisms and risk of acute myeloid leukemia(AML). Methods:This hospital-based case-control study included 120 AML patients and 210 cancer-free controls in a Chinese population. Three polymorphisms of XRCCS, XRCC6 and XRCC7 were genotyped using the polymerase chain reaction(PCR) or polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method. Results: We found that there was a significant decrease in risk of AML associated with the XRCC6-61 CG/GG genotype(adjusted odd ratio (OR)=0.55;95% confident interval(CI)=0.34-0.89) compared with the-61CC genotype. For the novel tandem repeat polymorphism (VNTR) in the XRCC5 promoter, we found when the XRCC5 six genotypes were dichotomized(i.e., 2R/2R, 2R/1R versus 2R/0R, 1R/1R, 1R/0R and 0R/0R), the latter group was associated with increased risk of AML(adjusted OR=1.67;95% CI=1.00-2.79) compared to 2R/ 2R+2R/1R genotype. However, the XRCC7 6721G>T polymorphism had no effect on risk of AML. Conclusion:The XRCC6-61C > G and XRCC5 2R/1R/0R polymorphisms, but not XRCC7 6721G > T polymorphism, could play an important role in the development of AML. Larger scale studies with more detailed data on environment exposure are needed to verify these findings.
机标关键词：DNAacute myeloid leukemiaAMLpolymerase chain reactiongenotypetandem repeatsignificantdevelopment
分类号：R5(内科学)
资助基金：国家自然科学基金(30571541)江苏省自然科学基金(BK2006233;BK2005161)Medicine Foundation of Jiangsu Province(H200506)Creative Science Foundation of Nanjing Medical University(CX2004002)
论文发表日期：2009-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 93-99 )
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