Chemical composition and antimicrobial activity of essential oil isolated from the cultured mycelia of Ganoderma japonicum
Dandan Liu
Zheng Hu
Zhigang Liu
Bo Yang
Wenjuan Tu
Liang Li
摘要：Objective:To explore a new natural antibiotic. Methods:The chemical composition of the essential oil from Ganoderma japonicum (G. japonicum) mycelia was analyzed by gas chromatography-mass spectrometry(GC-MS). The antimicrobial activity of the oil was evaluated against eighteen microorganisms, including bacteria, mildew and yeast by using a disc diffusion method. Furthermore, the minimum inhibitory concentrations(MIC) and the minimum bactericidal concentrations(MBC) of the essential oil against twelve clinical pathogens were determined. Results:The main components of the oil were nerolidol, decadienal, linaiool and benzyl alcohol. The antimicrobial results indicated that the oil inhibited all the tested bacterium, especially Methicillin-resistant Staphylococcus aureus (MRSA) in which the antibacterial activity exhibited a MBC of 1.03 mg/ml. Conclusion: The essential oil of G.japonicum mycelium has significant inhibitory activity. It is a potential medicinal resource that can be used as a natural antibiotic.
机标关键词：essential oilgas chromatography-mass spectrometryminimum inhibitory concentrationsantimicrobial activityantibacterial activityStaphylococcus aureuschemical compositionResults
分类号：R5(内科学)
资助基金：湖北省自然科学基金(2004ABA228)
论文发表日期：2009-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 168-172 )
英文信息