Relationship of GSTM1 and GSTT1 genetic variant and markers of oxidative stress and inflammation in smokers with coronary artery disease
ChanggaoZhou
Jianjin Tang
Mingwei Wang
Jianjun Yan
Qiming Wang
Jun Zhu
Zhijian Yang
Liansheng Wang
摘要：Objective: To investigate the role of glutathione S-transferase (GST) genetic variants and markcrs of oxidative stress and inflammation in smoking-related coronary artery disease (CAD) patients. Methods: Five hundred and thirty-five Chinese CAD patients were successfully gcnotyped. Plasma total antioxidant status (TAOS), glutathione, C-reactive protein (CRP), fibfinogen(FIB) and white blood cell count (WBC) were determined to evaluate the oxidative stress and inflammatory response. Results: GSTM1-0/ GSTT1-0 subjects had a higher CRP, FIB, WBC and GSH and a lower TAOS compared to patients with wild-type GSTM1/GSTT1 genes, but there was significant difference only with regards to TAOS. Smokers with the null genotype of GSTT1 had the highest CRP and the lowest TAOS and GSH when compared to the GSTT1-1 genotype with smoking status, or the GSTT1-0 genotype with non-smoking stares, or the GSTT1-1 genotypc with non-smoking status. However, we found no significant difference between these groups. Also, no significant interaction was observed between genotypes and smoking stares in determining CRP levels. Conclusion: Our results suggest that GST polymorphisms do not modify the effect of smoking on markers of oxidative stress and inflammation in Chinese CAD patients.
机标关键词：coronary artery diseaseoxidative stressGSTT1GSTM1significantgenotypedifferenceResults
分类号：R5(内科学)
资助基金：grants from the Natural ScienceFoundation of Jiangsu Province(BK2007254)国家自然科学基金(30871078)
论文发表日期：2009-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：5( 300-304 )
英文信息