Intrinsic control of axon regeneration
Zhigang He
摘要：Spinal cord injury disrupts the connections between the brain and spinal cord,often resulting in the loss of sensory and motor function below the lesion site. The most important reason for such permanent functional deficits is the failure of injured axons to regenerate after injury. In principle,the functional recovery could be achieved by two forms of axonal regrowth:the regeneration of lesioned axons which will reconnect with their original targets and the sprouting of spared axons that form new circuits and compensate for the lost function.Our recent studies reveal the activity of the mammalian target of rapamycin (mTOR) pathway,a major regulator of new protein synthesis,as a critical determinant of axon regrowth in the adult retinal ganglion neurons[1]. In this review,I summarize current understanding of the cellular and molecular mechanisms that control the intrinsic regenerative ability of mature neurons.
机标关键词：axon regenerationspinal cordmolecular mechanismsprotein synthesismotor functionunderstandingrapamycinstudies
分类号：R3(基础医学)
论文发表日期：2010-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：4( 2-5 )