A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population
Hua Huang
Juan Wu
Guangfu Jin
Hanze Zhang
Yanbing Ding
Zhaolai Hua
Yan Zhou
Yan Xue
Yan Lu
Zhibin Hu
Yaochu Xu
Hongbing Shen
摘要：Objective: Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 (TLR4) gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility to gastric cancer in a Chinese population. Methods: Two variations in the 5'-flanking region of TLR4 (rsl927914 T > C and rs 10759932 T > C) were genotyped by using the PCR-restriction fragment length polymorphism (RFLP) assay in a case-control study of 1,053 incident gastric cancer cases and 1,100 cancer-free controls in a Chinese population. Results: Individuals carrying the C allele of rsl0759932 had a significantly reduced risk of gastric cancer (adjusted OR = 0.81; 95%CI = 0.67-0.96), compared with the wild-type homozygote (TT), and the protective effect was not significantly different among subgroups stratified by age, sex, smoking, drinking and H.pylori infection status (P for heterogeneity > 0.05). No significant association was observed between rsl927914 and gastric cancer risk in this study population. Conclusion: The T to C allele substitution of rs 10759932 may play a protective role in gastric carcinogenesis in a Chinese population. Large studies with different ethnic populations are warranted to confirm these findings.
机标关键词：Chinese populationgastric cancertoll-like receptorgastric carcinogenesisdifferentprotective effectimmune responsesH.pylori
分类号：R3(基础医学)
资助基金：国家自然科学基金(30700684;30671814)江苏省自然科学基金(BK2008221)the Key Project of Nanjing Medical University(09NJMUZ12)
论文发表日期：2010-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 100-106 )
英文信息