Association of transforming growth factor-β1 gene variants with risk of coal workers' pneumoconiosis
Haiyang Qian
Zhifang Song
Meilin Wang
Xiaomin Jia
Aiping Li
Ye Yang
Lianlian Shen
Shasha Wang
Chunhui Ni
Jianwei Zhou
摘要：Objective: The aim of this case-control study was to explore whether five tagging single nucleotide poly-morphisms (tSNPs) within the transforming growth factor-β1 (TGF-β1) gene were involved in manifestation of inflammatory and fibrotic processes associated with coal workers' pneumoconiosis (CWP). Methods: The study included 508 CWP patients and 526 controls who were underground coal miners from Xuzhou Mining Business Group. Five tSNPs were selected from the HapMap and detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The single SNP analysis showed that the genotype frequencies of SNP2 (rs1800470, +869T/C, extron 1) and SNP5 (rs11466345, intron 5) in CWP cases were significantly different from those in controls. Multivariate logistic regression analysis revealed that SNP2 (rs1800470) CC genotype was associated with decreased risk of CWP (OR = 0.50, 95% CI = 0.32-0.78), which was evident among subgroups of those never smoke (OR = 0.40, 95%CI = 0.24-0.66), cases with stage Ⅱ (OR = 0.41, 95%CI = 0.22-0.76) and exposure period (< 28 y: OR = 0.54, 95%CI = 0.31-0.95; ≥28 y: OR = 0.52, 95%CI = 0.32-0.96). However, the SNP5 (rs11466345) GG genotype was associated with an increased risk of CWP (OR = 2.5, 95%CI = 1.36-4.57), and further stratification analysis showed that the risk of CWP was increased in both smoking an dnonsmoking groups, shorter and longer exposure groups, while the risk of CWP was only increased in patients with stage Ⅰ and Ⅱ. Conclusion: This study suggests that TGF-β1 polymorphisms may contribute to susceptibility of CWP.
机标关键词：genotypestratification analysisregression analysisexposurecontrolsstudystageprocesses
分类号：R3(基础医学)
资助基金：the National Natural Science Foundation of China(30872093)Research Foundation of Health Department of Jiangsu Province(H200628)
论文发表日期：2010-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息