The effects of diltiazem in renal transplantation patients treated with cyclosporine A
Wujun Xue
Yong Song
Puxun Tian
Xiaoming Ding
Xiaoming Pan
Hang Yan
Jun Hou
Xinshun Feng
Heli Xiang
Xiaohui Tian
摘要：Objective: To investigate the effects of diltiazem and cyclosporine A(CsA)combination therapy on protecting the kidney,promoting graft functioning and improving post-transplanted kidney recovery.Methods: The blood concentrations of CsA,the condition of the post-transplant kidney,the rate of acute rejection(AR),as well as hepatic and renal toxicity in 636 cases of renal transplant recipients were determined after being treated by CsA,with or without diltiazem.Results: Compared with the control group which received CsA,mycophenolate mofetil(MMF)and prednisolone(Pred)but lacked diltiazem,the group receiving these agents together with diltiazem required reduced dosage of CsA(P < 0.01),while blood concentrations of CsA were significantly increased(P < 0.01); the recovery time of graft function was reduced from(6.2±1.5)d to(3.9±1.4)d(P < 0.01),and the rate of AR was decreased from 13.2% to 7.9%(P < 0.01).Conclusion: In renal transplantation patients treated with CsA and diltiazem,blood concentrations of CsA were increased while the dosage was decreased.This efficient combination therapy reduced patients' economic burden,at the same time retained kidney function,promoted graft function recovery and decreased hepatic and renal toxicity and the rate of AR.
机标关键词：treatedcombination therapyfunction recoveryCsArenal transplantationacute rejectionrecovery timerequired
分类号：R3(基础医学)
资助基金：the "13115" Innovation Technology Project of Special Purpose of Shaanxi Province(2087ZDKG-67)the National Natural Science Foundation of China(30772096)the Natural Science Foundation of Shaanxi Province(2007C2C12)the Project of the National Science Foundation for Distinguished Young Scholars of First Affiliated Hospital of the Medical College of Xi'an Jiaotong University(2006YK4)the Science Research of Shaanxi Health Department(08D25)
论文发表日期：2010-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息