Arg462GIn and Asp541GIu polymorphisms in ribonuclease L and prostate cancer risk:a meta-analysis
Yuanyuan Mi
Qianqian Yu
Zhichao Min
Bin Xu
Lifeng Zhang
Wei Zhang
Ninghan Feng
Lixin Hua
摘要：Objective:The association between ribonuclease L (RNASEL) gene polymorphisms and prostate cancer risk has been widely reported,but the results of these studies remained controversial and underpowered.We performed a meta-analysis of 28 studies to evaluate the association between Arg462Gln and Asp541Glu polymorphisms in the RNASEL gene and prostate cancer risk.Methods:Odds ratios (ORs) with 95% confidence intervals (CIs)were estimated to assess the association between RNASEL polymorphisms and prostate cancer risk.Results:A significantly increased prostate cancer risk was found for the Arg462Gln polymorphism in Africans (Gln/Gin vs Arg/Arg:OR=2.50,95% CI=1.28-4.87;Gin/Gin vs Gln/Arg + Arg/Arg:OR=2.54,95% CI=1.30-4.95),but not in Europeans and Asians.Additionally,the Asp541 Glu polymorphism was associated with increased total prostate cancer risk (Glu-allele vs Asp-allele:OR=1.04,95% CI= 1.01-1.07;Glu/Glu vs Asp/Asp:OR=1.22,95% CI=1.03-1.46;Glu/Glu vs Glu/Asp + Asp/Asp:OR=1.09,95% CI=1.02-1.16).In the stratified analysis for the Asp541 Glu polymorphism,there was a significantly increased prostate cancer risk in Africans and Europeans,and in hospital-based prostate cancer cases.Conclusion:The meta-analysis results showed evidence that RNASEL Arg462Gln and Asp541 Glu polymorphisms are associated with prostate cancer risk and could be low-penetrance prostate cancer susceptibility biomarkers.
机标关键词：cancer riskprostate cancerGlumeta-analysisresultsstudiestotalfound
分类号：R3(基础医学)
资助基金：This study was supported by the program of key medical department of Jiangsu Province(XK17 200904)
论文发表日期：2010-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息