Tagging single nucleotide polymorphisms in the PPAR-γ and RXR-α gene and type 2 diabetes risk: a case-control study of a Chinese
Juan Du
Hui Shi
Ying Lu
Wencong Du
Yuanyuan Cao
Qian Li
Jianhua Ma
Xinhua Ye
Jinluo Cheng
Xiaofang Yu
Yanqin Gao
Ling Zhou
摘要：Peroxisome proliferator-activated receptor (PPAR-γ),which is mainly involved in adipocyte differentiation, has been suggested to play an important role in the pathogenesis of insulin resistance and atherosclerosis. We investigated the frequencies of two common tagging polymorphisms of the PPAR-γ gene and two of PPAR-α with minor allele frequency (MAF) ≥ 0.05 in the Chinese Han population and analyzed the correlation between the different genotypes and the risk of type 2 diabetes mellitus (T2DM). TaqMan(R) assay was performed to test the genotypes in T2DM patients (n = 1,105) and normal controls (n = 1,107). Serum adiponectin concentration was measured by ELISA kit. The variant genotypes rs17817276GG, rs3856806CT and rs3856806CT/TT of PPAR-γ were associated with T2DM, P = 0.023,0.037 and 0.018, respectively. Furthermore, the prevalence of haplotype GT in PPAR-γ was less frequent in the case subjects (0.3%) than in the controls (1.9%) [P < 0.001,OR(95%CI)=0.13 (0.06-0.31)]. Patients with genotype TT of rs3856806 had a higher serum level of adiponectin than those with the genotype CC and CT (P = 0.031 and 0.038, respectively). There was no statistically significant difference between patients and controls in genotype distribution of rs6537944 and rsl045570 of the RXR-α gene. The present study suggests that the variant genotypes in the PPAR-γ gene could decrease the risk for the development of T2DM in the Chinese Han population.
机标关键词：genotypeChinese Han populationPPAR-γcontrolsadiponectininsulin resistancediabetes mellitusT2DM
分类号：R3(基础医学)
资助基金：This study was supported by National Natural Science Foundation of China Grant(30771858)Jiangsu Provincial Natural Science Foundation Grant(BK2007229)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息