Single-dose and multiple-dose pharmacokinetics of zaltoprofen after oral administration in healthy Chinese volunteers
Lingjun Li
Pengcheng Ma
Yuping Cao
Lei Tao
Yue Tao
摘要：Zaltoprofen,a propionic acid derivative of non-steroidal anti-inflammatory drugs,has strong inhibitory effects on actue and chronic inflammation.A randomized,dose-escalating study was conducted to evaluate the pharmacokinetics of single and multiple oral doses of zaltoprofen in 12 healthy Chinese volunteers.Pharmacokinetics was determined from serial blood samples obtained up to 24 h after administration of a single dose of zaltoprofen at 80,160 or 240 mg and after multiple doses of zaltqorofen at 80 mg 3 times daily.The Cmax and AUC0-24 of zaltoprofen were found to be proportional to drug dose.Zaltoprofen was rapidly absorbed(tmax =1.46±0.83 h)and cleared(t1/2=4.96±2.97 h).Pharmacokinetic parameters after multiple doses were similar to those after single doses.Zaltoprofen was well tolerated.These results support a rid regimen of zaltoprofen for the management of acute and chronic inflammation.
机标关键词：Chinesemultipleinhibitory effectspropionic acidmanagementresultsstudyfound
分类号：R3(基础医学)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息