CASP8 promoter polymorphism, mRNA expression and risk of prostate cancer among Chinese men
Guangbo Fu
Jialin Tang
Meilin Wang
Chao Qin
Fu Yan
Qi Ding
Changjun Yin
Xinru Wang
Zhengdong Zhang
摘要：Caspase-8(CASP8) plays a key role in apoptosis. We examined by genotyping whether the-652 six-nucleotide insertion-deletion (6N ins/del) polymorphism in the CASP8 promoter region was associated with prostate cancer risk in a hospital-based case-control study of 406 Chinese prostate cancer patients and 408 age-matched cancer- free controls. Additionally, 23 prostate cancer tissues were analyzed for CASP8 mRNA expression. We found a significantly decreased prostate cancer risk for the 6N ins/del genotype [adjusted odds ratio (OR)=0.68; 95% con- fidence interval(CI)=0.51-0.92]and del/del genotype(OR=0.34; 95% CI=0.19-0.63) compared with the ins/ins genotype. The 6N del allele was associated dose-dependently with decreased prostate cancer risk (P<,trend>=0.001).RT-PCR showed that individuals with the 6N del allele had lower CASP8 mRNA levels than those with the ins/ ins genotype (P=0.024). These findings suggested that the CASP8-652 6N ins/del polymorphism may affect the susceptibility to prostate cancer and reduce prostate cancer risk among Chinese men.
机标关键词：CASP8Chineseprostate cancercancer riskgenotypeinscancer patientsodds ratio
分类号：R737.25(泌尿生殖器肿瘤)
资助基金：This study was partly supported by National Natural Science Foundation of China(30872084;30972444)the Key Program for Basic Research of Jiangsu Provincial Department of Education(08KJA330001)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息