Apparent diffusion coefficient in normal and abnormal pattern of intervertebral lumbar discs: initial experience
Gang Niu
Xuewen Yu
Jian Yang
Rong Wang
Shaojuan Zhang
Youmin Guo
摘要：The aim of the present study was to compare the relationship of morphologically defined non-bulging/herniated, bulging and herniated intervertebral lumbar discs with quantitative apparent diffusion coefficient (ADC). Thirty-two healthy volunteers and 28 patients with back pain or sciatica were examined by MRI. All intervertebral lumbar discs from L1 to S1 were classified according to morphological abnormality and degenerated grades. The ADC values of nucleus pulposus (NP) were measured and recorded. The significant differences about mean ADC values of NP were found between non-bulging/herniated discs and bulging discs as well as herniated discs (P < 0.05), whereas there were no significant differences in ADC values between bulging and herniated discs (P > 0.05). Moreover, statistically significant relationship was found in the mean ADC values of NP between "non-bulging/ herniated and non-degenerated discs" and "non-bulging/herniated degenerated discs" as well as herniated discs (P < 0.05). Linear regression analysis between ADC value and disc level revealed an inverse correlation (r = -0.18). The ADC map of the NP is a potentially useful tool for the quantitative assessment of componential and molecular alterations accompanied with lumbar disc abnormalities.
机标关键词：apparent diffusion coefficientexperiencesignificantLinear regression analysisrelationshipquantitative assessmentdifferencesADC
分类号：TP333.4(计算技术、计算机技术)
资助基金：This work was in part supported by the National Natural Foundation of China(30970797)Shaanxi Science and Technology Plan Projects(2008k09-1)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息