ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity
Min Lu
Qun Lu
Yong Zhang
Gang Tian
摘要：We investigated the relationship of apoB/apoAl ratio and coronary heart disease (CHD) in persons who were overweight or obese. The subjects were divided by the body mass indexes (BMI) into the normal weight group (n=397, BMI＜24 kg/m2) and the overweight group (n=400, BMI＞24 kg/m2). Our results showed that the overweight group had higher blood pressure [(130.15± 19.01) mmHg vs (123.66± 18.70) mmHg] and higher levels of blood sugar [(7.09±2.89) mmol/L vs (6.21 ±2.59) mmol/L], triglyceride [(1.93± 1.19) mmol/L vs (1.44 ±0.85)mmol/L], total cholesterol [(4.26± 1.06) mmol/L vs (4.09±0.99) mmol/L], low-density lipoprotein cholesterol (LDL-C) [(2.56±0.75) mmol/L vs (2.39±0.72) mmol/L], and apoB [(0.83 ±0.27) mg/L vs (0.78±0.23) mg/L],and a higher apoB/apoAl ratio (0.83 ± 0.27 vs 0.75 ± 0.25) and lower levels high-density lipoprotein cholesterol [(1.10 ± 0.26) mmol/L vs (1.21 ± 0.31) mmol/L] and apoAI [(1.04 ± 0.20) mg/L vs (1.08 ± 0.22) mg/L] than those of the normal weight group (all P ＜ 0.05). The prevalence of CHD in the over-weight group in the lowest LDL quartile was almost twice greater than that of the highest apoB/apoAl quartile, compared with the subjects in the lowest apoB/apoAl quartile. The higher apoB/apoAl quartile was in agreement with the higher prevalence of CHD.In the overweight and obesity group, the area under ROC curve (AUC) was the highest for apoB/apoAl (0.655).The cut-off point of apoB/apoAl for optimal sensitivity and specificity was at 0.80, with a sensitivity of 57.19％and a specificity of 71.72％. In conclusion, apoB and apoAl were simple clinical indicators, and the apoB/apoAl ratio was closely related with CHD in overweight and obese patients. The apoB/apoAl ratio may provide some useful information in the differential diagnosis.
机标关键词：coronary heart diseasenormal weightinformation inblood pressurerelationshiplevelsCHDblood sugar
分类号：R541.4(心脏、血管（循环系）疾病)R589.2(内分泌腺疾病及代谢病)
资助基金：National High-Tech Research and Development Program of China(2006AA02A406)Natural Science Foundation of China(30871042)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息