Bisoprolol reverses down-regulation of potassium channel proteins in ventricular tissues of rabbits with heart failure
Xi Li
Tingzhong Wang
Ke Han
Xiaozhen Zhuo
Qun Lu
Aiqun Ma
摘要：Remodeling of ion channels is an important mechanism of arrhythmia induced by heart failure (HF). We investigated the expression of potassium channel encoding genes in the ventricles of rabbit established by volumeoverload operation followed with pressure-overload. The reversible effect of these changes with bisoprolol was also evaluated. The HF group exhibited left ventricular enlargement, systolic dysfunction, prolongation of corrected QT interval (QTc), and increased plasma brain natriuretic peptide levels in the HF rabbits. Several potassium channel subunit encoding genes were consistently down-regulated in the HF rabbits. After bisoprolol treatment, heart function was improved significantly and QTc was shortened. Additionally, the mRNA expression of potassium channel subunit genes could be partially reversed. The down-regulated expression of potassium channel subunits Ky4.3, Kv1.4, KvLQTl, mink and Kit 2.1 may contribute to the prolongation of action potential duration in the heart of rabbits induced by volume combined with pressure overload HF. Bisoprolol could partially reverse these down-regulations and improve heart function.
机标关键词：heart failurepotassium channelbrain natriuretic peptidepressure overloadleft ventricularfunctionchannel encodingaction potential
分类号：R541.6(心脏、血管（循环系）疾病)
资助基金：the State Key Program of the National Natural Science Foundation of China(30830051)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息