Cardioprotective activity of alcoholic extract of Tinospora cordifolia (Willd.) Miers in calcium chloride-induced cardiac arrhythmia in rats
Ashish Kumar Sharma
Kunal Kishore
Divya Sharma
B.P Srinivasan
Shyam Sunder Agarwal
Ashok Sharma
Santosh Kumar Singh
Samir Gaur
Vijay Singh Jatav
摘要：The present study investigated the antiarrhythmic activity of alcoholic extract of Tinospora cordifolia (T. cordifolia) in CaCl2 induced arrhythmia. CaCl2 (25 mg/kg) was administered by intravenous infusion (iv) to produce arrhythmia in rats. The animals were then treated with T. cordifolia extract (150, 250, and 450 mg/kg) and verapamil (5 mg/kg,iv). Lead II electrocardiogram was monitored. Plasma calcium, sodium and potassium levels were measured. In CaCl2 induced arrhythmia, heart rate was decreased by 41.10％, T. cordifolia at 150, 300, and 450 mg/kg decreased the heart rate by 26.30％, 29.16％, and 38.29％, respectively, and verapamil reduced the heart rate by 9.70％ compared to the normal group. The PQRST waves were normalized and atrial and ventricular fibrillation was controlled in rats treated with verapamil and T. cordifolia. CaCI2 increased calcium and sodium levels and decreased potassium levels in blood. T. cordifolia dose-dependently decreased calcium and sodium levels and increased potassium levels. Hence, T. cordifolia can be used in antiarrhythmic clinical settings and beneficial in atrial and ventricular fibrillation and flutter and may be indicated in ventricular tachyarrhythmia.
机标关键词：ventricular fibrillationlevelsheart ratepotassiumintravenous infusionCaCl2treatedsettings
分类号：R541.7(心脏、血管（循环系）疾病)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息