Effects of minocycline on the expression of NGF and HSP70 and its neuroprotection role following intracerebral hemorrhage in rats
Jingnan Pu
Wei Shi
Zizhang Wang
Ruizhi Wang
Zhenyu Guo
Chongxiao Liu
Jianjun Sun
Ligui Gao
Ren Zhou
摘要：The present study was aimed to investigate the effects of minocycline (MC) on the expression of nerve growth
factor (NGF) and heat shock protein 70 (HSP70) following intracerebral hemorrhage (ICH) in rats, and explore
the neuroprotective function of MC. Seventy-eight male SD rats were randomly assigned to three groups: the ICH
control group (n = 36), ICH intervention group (n = 36) and sham operation group (n = 6). The ICH control group
and ICH intervention group were subdivided into 6 subgroups at 1, 2, 4, 5, 7 and 14 d after ICH with 6 rats in
each subgroup. Type IV collagenase was injected into the basal nuclei to establish the ICH model. All rats showed
symptoms of the nervous system after the model was established, and the sympotsm in the ICH control group
were more serious than the ICH intervention group. The number of NGF-positive cells and HSP70-positive cells
in the ICH intervention group was higher than that of the ICH control group. MC administration by intraperito
neal injection can increase the expression of NGF and HSP70. MC may inhibit the activation of microglia, the in
flammatory reaction and factors, matrix metalloproteinases and apoptosis, thus protecting neurons. The change of
the expression of NGF and HSP70 may be involved in the pathway of neuroprotection by MC.
机标关键词：intracerebral hemorrhageHSP70NGFcontrolType IV collagenaseheat shock proteinnervous systemminocycline
分类号：R965(药理学)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息