Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma
Jennifer M. Bratt
Amir A. Zeki
Jerold A. Last
Nicholas J. Kenyon
摘要：Exhaled breath nitric oxide (NO) is an accepted asthma biomarker. Lung concentrations of NO and its amino acid precursor, L-arginine, are regulated by the relative expressions of the NO synthase (NOS) and arginase isoforms. Increased expression of arginase I and NOS2 occurs in murine models of allergic asthma and in biopsies of asthmatic airways. Although clinical trials involving the inhibition of NO-producing enzymes have shown mixed results, small molecule arginase inhibitors have shown potential as a therapeutic intervention in animal and cell culture models. Their transition to clinical trials is hampered by concerns regarding their safety and potential toxicity. In this review, we discuss the paradigm of arginase and NOS competition for their substrate L-arginine in the asthmatic airway. We address the functional role of L-arginine in inflammation and the potential role of arginase inhibitors as therapeutics.
机标关键词：L-arginineclinical trialsallergic asthmanitric oxidecell cultureamino acidparadigmresults
分类号：R562.25(呼吸系及胸部疾病)
资助基金：National Institute of Environmental Health Sciences funded training program in Environmental Health Sciences(T32 ES007058-33)to Jennifer M.Bratt,CTSC K12 Award(UL1RR024146KL2RR024144)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息