The distribution of HLA-A,-B,and -DRB1 alleles and haplotypes in inhabitants of Guizhou Province of China
Qinqin Pan
Su Fan
Xiaoyan Wang
Xing Zhao
Meng Pan
Chengya Wang
Jie Shen
摘要：The present study was aimed to analyze the frequencies of human leukocyte antigen (HLA)-A,-B, and -DRBI alleles and A-B-DRBI, A-B, A-DRBI and B-DRBI haplotypes in inhabitants of Guizhou province, China. All samples were typed in the HLA-A,-B,and -DRB1 loci using the polymerase chain reaction-reverse sequence specific oligonucleotide probe (PCR-rSSOP) method and HLA polymorphisms were analyzed. A total of 18 HLA-A,31 HLA-B, and 13 HLA-DRBI alleles were found in the Guizhou population. The first two frequent alleles in the HLA-A,-B, and -DRBI loci were A*11(30.72%) and A*02(30.65%), B*40(16.27%) and B*46(16.27%a),and DRBI*09(15.91%) and DRBI*15(13.51%), respectively. The most common haplotype was A*02-B*46DRBI*09(5.59%) in A-B-DRBI, A*02-B*46(11.73%) in A-B, B*46-DRBI*09(7.49%) in B-DRBI, and A*02DRBI*09(8.08%) in A-DRBI. Some haplotypes with strong linkage disequilibrium (LD) were found not only in the common haplotypes, such as A*33-B*58, B*30-DRBI*07, and B*33-DRBI*03, but also in the rare haplotypes, such as A*01-B*37, B*37-DRBI*10, and A*01-DRBI*10. Guizhou inhabitants shared some characteristics of the Southern Chinese population but also had their own unique features. Overall, HLA polymorphism in Guizhou population was more consistent with that of Chengdu population than that of other populations in China.
机标关键词：ChinaHLA-Bhuman leukocyte antigenlinkage disequilibriumChinese populationGuizhou provincefoundSouthern
分类号：R394(医学遗传学)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息