Iptakalim, a novel ATP-sensitive potassium channel opener,inhibits pulmonary arterial smooth muscle cell proliferation bydownregulation of PKC-α
Xiangrong Zuo
Feng Zong
Hui Wang
Qiang Wang
Weiping Xie
Hong Wang
摘要：Iptakalim is a new ATP-sensitive potassium (KATP) channel opener,and it inhibits the proliferation of pulmonary arterial smooth muscle cells (PASMCs) and pulmonary vascular remodeling.However,the underlying mechanism remains unclear.In the present study,we found that iptakalim significantly decreased pulmonary artery pressure,inhibited pulmonary ariery remodeling and PKC-α overexpression in chronic hypoxia in a rat pulmonary hypertension model.Iptakalim reduced hypoxia-induced expression of PKC-α,and abolished the effect of hypoxia on PASMC proliferation significantly in a dose-dependent manner in vitro.Moreover,these effects were abolished by glibenclamide,a selective KATP channel antagonist.These results indicate that iptakalim inhibits PASMC proliferation and pulmonary vascular remodeling induced by hypoxia through downregulating the expression of PKC-α.Iptakalim can serve as a novel promising treatment for hypoxic pulmonary hypertension.
机标关键词：potassium channelnovelcell proliferationpulmonary vascular remodelingpulmonary hypertensionsmooth muscle cellspulmonary arterychronic hypoxia
分类号：R965(药理学)
资助基金：the National Natural Science Foundation of China(30971319)the "Six Talent Peak"Project of Jiangsu Province(08-B)Open Project Program of the Key Disciplines of the Public Health Department of Jiangsu Province(XK13_200902)
论文发表日期：2011-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息