PET imaging for receptor occupancy: meditations on calculation and simplification
Yumin Zhang
Gerard B. Fox
摘要：This invited mini-review briefly summarizes procedures and challenges of measuring receptor occupancy with positron emission tomography.Instead of describing the detailed analytic procedures of in vivo ligand-receptor imaging,the authors provide a pragmatic approach,along with personal perspectives,for conducting positron emission tomography imaging for receptor occupancy,and systematically elucidate the mathematics of receptor occupancy calculations in practical ways that can be understood with elementary algebra.The authors also share insights regarding positron emission tomography imaging for receptor occupancy to facilitate applications for the development of drugs targeting receptors in the central nervous system.
机标关键词：receptor occupancypositron emission tomographydevelopmentpragmaticpracticalapproachcentral
分类号：R811(放射医学)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息