Bromocriptine enhances the uptake of 99mTc-MIBI in patients with hepatocellular carcinoma
Xiangting Chai
Qiaoyu Liu
Wenyu Shao
Feng Zhang
Xuehao Wang
Hai Wang
摘要：99mTc-methoxyisobutyl isonitrile (MIBI) is a suitable transport substrate for the multidrug resistance gene product P-glycoprotein (P-gp) and widely used for tumor imaging.Bromocriptine has been shown to inhibit the ATPase activity and the function of P-gp.We hypothesized that bromocriptine could promote the accumulation of MIBI by inhibiting P-gp activities,a feature that can be taken advantage of for enhancing 99mTc-MIBI imaging.In the current study,we sought to investigate whether bromocriptine enhanced the uptake of 99mTc-MIBI in hepatocellular carcinoma patients.Sixty primary hepatocellular carcinoma patients received 99mTc-MIBI single photon emission computer tomgraphy (SPECT) prior to surgery.99mTc-MIBI SPECT was performed 15 and 120 min after injection of 20 mCi 99mTc-MIBI,and early uptake,delayed uptake (L/Nd),and washout rate (L/Nwr) of 99mTc-MIBI were obtained.In addition,a second 99mTc-MIBI SPECT was performed according to the same method 48 h after bromocriptine administration.We found that,prior to bromocriptine administration,significant MIBI uptake in tumor lesions was noted in only 10 (16.7％,10/60) patients with hepatocellular carcinoma.No significant MIBI uptake was observed in the tumor lesions of the remaining 50 (83.3％,50/60) hepatocellular carcinoma patients.Following bromocriptine administration,all the patients without apparent MIBI uptake demonstrated significant MIBI uptake on 99mTc-MIBI SPECT (P ＜ 0.05).Our findings indicate that bromocriptine enhances the uptake of 99mTc-MIBI in patients with hepatocellular carcinoma.
机标关键词：hepatocellular carcinomasingle photon emissionmultidrug resistancegene product
分类号：S858.285.3(动物医学（兽医学）)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息