Sitagliptin, sitagliptin and metformin, or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats
Ashish Kumar Sharma
Akash Sharma
Rita Kumari
Kunal Kishore
Divya Sharma
Bharthu ParthsarthiSrinivasan
Ashok Sharm
Santosh Kumar Singh
Samir Gaur
Vijay Singh Jatav
Prashant Sharma
Varnika Srivastava
Sneha Joshi
Megha Joshi
Prashant Kumar Dhakad
Davender Singh Kanawat
Akanksha Mishra
Anil Sharma
Dharmendra Singh
Ravinder Pal Singh
Himmat Singh Chawda
Rambir Singh
Sachin Kumar Raikwar
Muneem Kumar Kurmi
Pankaj Khatri
Ashutosh Agarwal
Arshee Munajjam
摘要：Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamide-streptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitrptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35 (P ＜ 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35 (P ＜ 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes.
机标关键词：weight gaintissue regenerationnerve cells
分类号：Q959.468(动物分类学（系统动物学）)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息