Preliminary feasibility and hemodynamic performance of a newly-developed self-expanding bioprosthesis and 16-F delivery system in transcatheter aortic valve implantation in sheep
Jing Cai
Yanhui Sheng
Shijiang Zhang
Wei Sun
Rong Yang
Liping Miao
Xiangqing Kong
摘要：We sought to evaluate the feasibility and hemodynamic performance of a new self-expanding bioprosthesis and 16-F delivery system in sheep.A 23-mm new self-expanding aortic bioprosthesis was implanted in sheep (n =10) with a 16-F catheter via the right common carotid artery.Each sheep underwent angiography and coronary angiography before intervention,immediately and 1 h after stent implantation.Electrocardiographic monitoring was carried out during and 2 h after the procedure.Transthoracic echocardiography was employed to detect hemodynamic performance before intervention,immediately and 1 and 2 h after stent implantation.All sheep were euthanized 2 h after successful implantation for macroscopic inspection.In all cases,the new self-expanding aortic bioprosthesis was successfully delivered to the aortic root and released with a 16-F catheter.Successful implantation was achieved in 8 of 10 sheep.Hemodynamic performance and device position of successful implantation were stable 2 h after device deployment.Atrioventricular block was not observed.We conclude that it is feasible to implant the new self-expanding aortic valve with a 16-F delivery system into sheep hearts via the retrograde route.
机标关键词：stent implantationcommon carotid arterycoronary angiographyaortic valveaortic root
分类号：Q136(生物形态学)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息