Hsa-mir-499 rs3746444 polymorphism and cancer risk:a meta-analysis
Peng Zou
Lin Zhao
Haitao Xu
Ping Chen
Aihua Gu
Ning Liu
Peng Zhao
Ailin Lu
摘要：MicroRNAs (miRNAs) are gene regulators involved in numerous diseases including cancer,heart disease,neurological disorders,vascular abnormalities and autoimmune conditions.Although hsa-mir-499 rs3746444 polymorphism was shown to contribute to the susceptibility of multiple genes to cancer,the data have yielded conflicting results.Therefore,this meta-analysis was performed to provide a comprehensive assessment of potential association between hsa-mir-499 rs3746444 polymorphism and cancer risk.In this meta-analysis,a total of 9 articles regarding 10 eligible case-control studies in English (including 6134 cases and 7141 controls) were analyzed.No significant association between hsa-mir-499 rs3746444 polymorphism and overall cancer risk was demonstrated.However,an increased risk was observed in the subgroup of breast cancer patients (G allele vs A allele:OR =1.10,95％ CI =1.00-1.20; Pheterogeneity =0.114; I2 =53.9％) and population-based studies (G allele vs Aallele:OR =1.12,95％ CI =1.00-1.25; Pheterogeneity =0.062; I2 =64.0％).The findings suggested an association between hsa-mir-499 rs3746444 polymorphism and increased risk to breast cancer.
机标关键词：breast cancercomprehensive assessmentcancer riskcancer patients
分类号：R730.2(一般性问题)
资助基金：China Natural Science Foundation(30901534)Jiangsu Province Natural Science Foundation(BK2009444)Grant for the 135 Key Medical Project of Jiangsu Province(XK201117)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息