Immunoexpression and prognostic role of p53 in different subtypes of epithelial ovarian carcinoma
Lihong Chen
Lianxiang Li
Feng Chen
Dalin He
摘要：We sought to investigate the significance of p53 expression for epithelial ovarian carcinoma.In this study,we used immunohistochemical method to investigate the expression patterns of p53 in different subtypes of epithelial ovarian carcinoma.We found that the expressions of p53 protein in epithelial ovarian cancer (pituita,serosity and intima) were 88.9％,75％ and 100％,respectively,while the recurrence rates among three cancer subtypes were significantly different (33.3％,12.5％ and 0％,respectively; P ＜ 0.05).Compared with patients without lymph node metastasis,the expression of p53 in patients with lymph node metastasis was significantly strong (68.75％and 100％,respectively; P ＜ 0.05).However,the recurrence rate in the patients with lymph node metastasis (40％) was higher than that without lymph node metastasis (6.25％,P ＜ 0.05).The expressions of p53 protein in ovarian cancer between Ⅰ - Ⅱ (25％) stage and Ⅱ - Ⅳ stage (100％) were significantly different (P ＜ 0.05),and the recurrence rates between the two groups were significantly different (0％ and 31.25％,respectively,P ＜ 0.05).Therefore,p53 protein has an intimate relationship with the malignant degree and the prognosis of ovarian cancer.
机标关键词：lymph node metastasisepithelial ovarian cancerovarian carcinomaimmunohistochemical methodrecurrence rate
分类号：R737.31(泌尿生殖器肿瘤)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
英文信息