A germline variant N375S in MET and gastric cancer susceptibility in a Chinese population
Yao Liu1
Qin Zhang1
Chuanli Ren2
Yanbing Ding3
Guangfu Jin4
Zhibin Hu4
Yaochu Xu1
Hongbing Shen5
1.Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China2.Medical Laboratory, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225001, China3.Department of Gastroenterology, Yangzhou First People's Hospital, Yangzhou, Jiangsu 225009, China4.Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China;Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center,Nanjing Medical University, Nanjing, Jiangsu 210029, China5.Department of Epidemiology and Biostatistics, MOE Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029, China;Medical Laboratory, Northern Jiangsu People's Hospital, Yangzhou, Jiangsu 225001, China
摘要：MET tyrosine kinase and its ligand,hepatocyte growth factor (HGF),play a pivotal role in the activties of tumor cells.A germline missense variant in exon 2 of the MET gene,N375S (rs33917957 A＞G),may alter the binding affinity of MET for HGF and thus modify the risk of tumorigenesis.In this study,we performed a case-control study to assess the association between N375S and gastric cancer risk in 1,681 gastric cancer cases and 1,858 cancer-free controls.Logistic regression analysis was applied to estimate crude and adjusted odds ratios (ORs) and 95％ confidence intervals (CIs) for the associations between genotypes and gastric cancer risk.We found that MET N375S variant genotypes (NS/SS) were associated with a significantly decreased risk of gastric cancer (OR =0.78,95％ CI =0.63-0.96,P =0.021) compared with the wildtype homozygote (NN).The finding indicates that this germline variant in MET may decrease gastric cancer susceptibility in Han Chinese.
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分类号：R735.2(消化系肿瘤)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
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