Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats
Xiaozheng Zhong1
Xiaoyu Li2
Lingling Qian1
Yiming Xu3
Yan Lu1
Jing Zhang4
Nan Li1
Xudong Zhu4
Jingjing Ben1
Qing Yang1
Qi Chen2
1.Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China2.Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, Jiangsu 210029, China;State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing Jiangsu 210029, China3.State Key Laboratory of Reproductive Medicine,Nanjing Medical University,Nanjing,Jiangsu 210029,China4.State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing Jiangsu 210029, China
摘要：Glycine is a well-documented cytoprotective agent.However,whether it has a protective effect against myocardial ischemia-reperfusion injury in vivo is still unknown.By using an open-chest anesthetized rat model,we found that glycine reduced the infarct size by 21％ in ischemia-reperfusion injury rats compared with that in the vehicletreated MI/R rats.The left ventricular ejection fraction and fractional shortening were increased by 19.11％ and 30.98％,respectively,in glycine-treated rats.The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment.Importantly,administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium,which was accompanied by suppression of phosphorylated p38 mitogenactivated protein kinase and c-Jun NH2-terminal kinase,as well as the Fas ligand.These results suggest that glycine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis.
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分类号：R541(心脏、血管（循环系）疾病)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
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