Hydrogen-rich saline protects against ultraviolet B radiation injury in rats
Ze Guo1
Bingrong Zhou1
Wei Li1
Xuejun Sun2
Dan Luo1
1.Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China2.Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China
摘要：Exposure of skin to solar ultraviolet (UV) radiation induces photo-damage.Ultraviolet B (UVB) is the major component of UV radiation which induces the production of reactive oxygen species (ROS) and plays an important role in photo-damage.Hydrogen gas reduces ROS and alleviates inflammation.In this study,we sought to demonstrate that hydrogen-rich saline has the effect on skin injuries caused by UVB radiation.UVB radiation was irradiated on female C57BL/6 rats to induce skin injury.Hydrogen-rich saline and nitrogen-rich saline were administered to rats by intraperitoneal injection.Skin damage was detected by microscope after injury.UVB radiation had a significant affection in tumor necrosis factor alpha,interleukin (IL)-1β and IL-6 levels,tissue superoxide dismutase,malondialdehyde and nitric oxide activity.Hydrogen-rich saline had a protective effect by altering the levels of these markers and relieved morphological skin injury.Hydrogen-rich saline protected against UVB radiation injury,possibly by reducing inflammation and oxidative stress.
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分类号：R751(皮肤病学)
论文发表日期：2012-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
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