From nerve to blood vessel: a new role of Olfm2 in smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells
Ning Shi
Shi-You Chen
摘要：Vascular smooth muscle cell (SMC) differentiation is an important process in vasculogenesis and angiogenesis during embryonic development.The alterations in the differentiated state in SMCs contribute to a variety of major cardiovascular diseases such as atherosclerosis,hypertension,restenosis and vascular aneurysm[1-2].A better understanding of the cellular and molecular mechanisms that control SMC differentiation is essential to help develop new approaches to both prevent and treat these diseases.Therefore,development of reliable and reproducible in vitro cellular models in order to study the differentiation mechanisms is important although it has been challenging because of intrinsic peculiarities of SMC.
机标关键词：
分类号：R394.1(医学遗传学)
资助基金：This work was supported by grants from National Institutes of Health (HL107526)This work was supported by grants from National Institutes of Health (HL119053)This work was supported by grants from National Institutes of Health (and HL123302 to SYC)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）