Dominant-negative inhibition of glucose-dependent insulinotropic polypeptide impairs function of β cells in transgenic pigs
JunLin Cheng
Ying Wang
Zhengwei Zhang
Yong Jin
QianKun Li
RongGen Want
Yan Wang
摘要：Dear Editor:
Glucose-dependent insulinotropic polypeptide (GIP) and proglucagon product glucagon-like peptide-1 (GLP-1) and their corresponding receptors promote secretion of glucose-dependent insulin[1] and may be responsible for up to 70％ of postprandial insulin secretions[2].A diminished incretin effect is typical for type 2 diabetes mellitus (T2DM) patients and their normoglycemic first-degree relatives due to reduced insulinotropic action of GIP[3].Desensitization of the GIP/GIPR axis[4],down-regulation of GIP receptor (GIPR) on β cells[5],and variation in the GIPR gene[6] all contribute to reduced insulinotropic activity of GIP.
机标关键词：
分类号：R714.256(产科学)
资助基金：The study was funded by the National Basic Research Program of China (973 Program.No.2011CBA01003)
论文发表日期：2015-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）