Evaluation of atherosclerotic lesions in cholesterol-fed mice during treatment with paclitaxel in lipid nanoparticles: a magnetic resonance imaging study
Aline D.Lima
Ning Hua
Raul C.Maranh(a)o
James A.Hamilton
摘要：Cholesterol-core nanoparticles (LDE) have been shown to be recognized by low-density lipoprotein receptors (LDLR) after administration;therefore,LDE is an ideal vehicle to deliver drug with targeting property.Paclitaxel,when incorporated into LDE,promotes atherosclerosis regression with reduced drug toxicity in rabbits through LDLR.Here,we tested whether LDE-paclitaxel could still be effective in reducing diet-induced atherosclerosis in a mouse model without LDLR.Nineteen LDLR knockout male mice were fed 1％ cholesterol for 12 weeks.Then,12 animals received 4-weekly intraperitoneal LDE-paclitaxel (4 mg/kg) while 7 controls received saline solution.On week 12 and 16,in vivo MRI of the aortic roots was performed.Aorta macroscopy was made after euthanasia.Reduction of atherosclerotic lesions was observed.LDE-paclitaxel treatment resulted in reduction of wall area (14％) and stenosis (22％) by MRI and 33％ by macroscopy.Thus,LDE-paclitaxel may produce pharmacological effects through LDE uptake by mechanisms other than LDLR.
机标关键词：pharmacological effectsdrug toxicitymouse modelmale mice
分类号：R95(药事管理)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 116-121 )
英文信息