Comparative effects of plant oils and trans-fat on blood lipid profiles and ischemic stroke in rats
Haiyu Guo
Young-Hwan Ban
Yeseul Cha
Tae-Su Kim
Sung-Pyo Lee
Eun Suk An
Jieun Choi
Da Woom Seo
Jung-Min Yon
Ehn-Kyoung Choi
Yun-Bae Kim
摘要：Since plant oils are believed to be better than animal fats for cerebrovascular and cardiovascular diseases,the effects of various plant oils and trans-fat on blood lipid profiles and ischemic stroke were investigated.SpragueDawley rats were fed a diet containing the oils or trans-fat,and then body weights,blood lipids,and effects on brain infarction and physical dysfunction induced by middle cerebral artery occlusion (MCAO) were analyzed.All the oils and trans-fat,except perilla oil,significantly increased body fats and body weight gain.Sesame oil and trans-fat specifically increased blood cholesterols and triglycerides,respectively,while perilla oil decreased both cholesterols and triglycerides.Perilla oil not only attenuated cerebral infarction,but also restored locomotor activity and rota-rod performances of MCAO rats.It is suggested that perilla oil among oils and fats could be the first choice to reduce the risk of metabolic syndrome and ischemic stroke.
机标关键词：ischemic strokecardiovascular diseasesmiddle cerebral arterycerebral infarctionmetabolic syndromelocomotor activitybrain infarctionweight gain
分类号：R332(人体生理学)
资助基金：the "Food Functionality Evaluation Program" under the Ministry of Agriculture,Food and Rural Affairs and partly Korea Food Research Institute (G2015)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 122-129 )
英文信息