Ultrasonographic evaluation of enthesitis in patients with ankylosing spondylitis
Huayong Zhang
Jun Liang
Junlan Qiu
Fan Wang
Lingyun Sun
摘要：The aim of this study was to assess sensitivity and responsiveness of power Doppler ultrasound (PDUS) in detecting enthesitis for ankylosing spondylitis (AS) patients compared to clinical examinations.Twenty AS patients initiating etanerceptumderwent clinical and PDUS examinations of six bilateral entheseal sites at baseline and after 1,2 and 3 months of treatment.Clinical and PDUS examinations identified at least one entheseal lesion in nine (45％) and 19 (95％) patients,respectively.Furthermore,of 240 entheseal sites examined in these 20 patients,PDUS detected 123 entheseal lesions (51.3％ of sites),compared with only 47 entheseal lesions (19.6％) detected by clinical examination (P＜0.05).The entheseal lesions found on PDUS were most commonly identified by calcification (33.3％),tendon edema (29.2％),abnormal blood flow (25.8％),a thickened tendon (22.1％),cortical irregularity (12.9％),bony erosions (9.6％) and bursitis at the tendon insertion to the bone cortex (7.1％).Improvements in clinical symptoms and laboratory parameters,and significant decreases in PDUS scores were observed following treatment with etanercept.Improvements in PDUS scores continued during follow-up in patients who entered remission following treatment.In conclusion,PDUS improves detection of structural and inflammatory abnormalities of the enthesis in AS compared to physical examination.In addition,PDUS may be useful inascertaining medications.
机标关键词：ankylosing spondylitisphysical examinationDoppler ultrasoundblood flow
分类号：R593.22A(全身性疾病)
资助基金：the National Natural Science Foundation of China(81671608)the National Natural Science Foundation of China(81202350)the National Natural Science Foundation of China(81571586 and 81302559)Pfizer Competitive Grant(WS1620920)Jiangsu Six Talent Peaks Project(2015-WSN-074)Jiangsu 333 High Level Talents Project,Jiangsu Government Scholarship for Overseas Studies,Jiangsu Health International Exchange Program sponsorship,Nanjing Young Medical Talents Project and Nanjing Health Bureau Key Project(ZKX15018)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 162-169 )
英文信息