Association of three single nucleotide polymorphisms of ESR1 with breast cancer susceptibility: a meta-analysis
Xu Hu
Linfei Jiang
Chenhui Tang
Yuehong Ju
Li Jiu
Yongyue Wei
Li Guo
Yang Zhao
摘要：Expression of estrogen receptors is correlated with breast cancer risk,but inconsistent results have been reported.To clarify potential estrogen receptor (ESR)-related breast cancer risk,we analyzed genetic variants of ESR1 in association with breast cancer susceptibility.We performed a meta-analysis to investigate the association between rs2234693,rs1801132,and rs2046210 (single nucleotide polymorphisms of ESR1),and breast cancer risk.Our analysis included 44 ease-control studies.For rs2234693,the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype.For rs2046210,the AA,GA,or GA + GG genotype had a much higher risk compared to the GG genotype.No significant association was found for the rs1801132 polymorphism with breast cancer risk.This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms of ESR1 and breast cancer risk.The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity.
机标关键词：breast cancercancer riskestrogen receptors
分类号：R737.9(泌尿生殖器肿瘤)
资助基金：the National Natural Science Foundation of China(81373102 to YZ)the National Natural Science Foundation of China(61301251 to LG)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(12KJB310003)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 213-225 )
英文信息