(+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines
Lei Chang
Chun-Yu Yin
Hai-Yin Wu
Bin-Bin Tian
Yan Zhu
Chun-Xia Luo
Dong-Ya Zhu
摘要：Stroke is one of the leading causes of disability and death globally.It occurs when a major artery is occluded in thebrain and leads to death of cells within the injured tissue.(+)-Bomeol,a simple bicyclic monoterpene extracted from traditional Chinese medicine,is widely used in various types of diseases.However,no study has proved the effects of (+)-borneol on functional recovery from permanent ischemic stroke and the mechanism is still unknown.Here,we report that in the rat model of permanent cerebral ischemia,we found that (+)-borneol (1.0 mg/kg) significantly ameliorated infarct size and neurological scores via reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in a dose dependent manner.Notably,(+)-bomeol showed long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke,which decreased the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task,at least in part through reducing loss of dendritic spines in the length,brunch number and density.These findings suggest that (+)-borneol could serve as a therapeutic target for ischemic stroke.
机标关键词：proinflammatory cytokinesischemic stroketraditional Chinese medicinenitric oxide synthasecerebral ischemiarat modelused in
分类号：R363(病理学)
资助基金：grants from National Natural Science Foundation of China(91232304)grants from National Natural Science Foundation of China(31530091)grants from National Natural Science Foundation of China(81571188 and 81222016)the Natural Science Foundation of Jiangsu Province(BK2011029)Distinguished Young Scientists Fund(BK20130040)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 306-314 )
英文信息