Moringa oleifera-based diet protects against nickel-induced hepatotoxicity in rats
Oluyomi Stephen Adeyemi
Cincin Sokolayemji Aroge
Musbau Adewumi Akanji
摘要：Multiple health-promoting effects have been attributed to the consumption ofMoringa oleifera leaves,as part of diet without adequate scientific credence.This study evaluated the effect of M.oleifera-based diets on nickel (Ni)-induced hepatotoxicity in rats.Male rats assigned into six groups were given oral administration of 20 mg/kg body weight nickel sulfate in normal saline and either fed normal diet or M.oleifera-based diets for 21 days.All animals were sacrificed under anesthesia 24 hours after the last treatment.Ni exposure elevated the rat plasma activities of alanine transaminase,aspartate transaminase and alkaline phosphatase significantly.Ni exposure also raised the levels of triglyceride,total cholesterol and low-density lipoprotein cholesterol while depleting the high-density lipoprotein cholesterol concentration.Further,Ni exposure raised rat plasma malondialdehyde but depleted reduced glutathione concentrations.The histopathological presentations revealed inflammation and cellular degeneration caused by Ni exposure.We show evidence that M.oleifera-based diets protected against Ni-induced hepatotoxicity by improving the rat liver function indices,lipid profile as well as restoring cellular architecture and integrity.Study lends credence to the health-promoting value ofM.oleifera as well as underscores its potential to attenuate hepatic injury.
机标关键词：alkaline phosphatasealanine transaminasereduced glutathioneoral administrationnickel sulfateliver functionhepatic injurybody weight
分类号：R285.5(中药学)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 350-357 )
英文信息