Exosomes and their role in the micro-/macro-environment: a comprehensive review
Naureen Javeed
Debabrata Mukhopadhyay
摘要：The importance of extracellular vesicles (EVs) in cell-cell communication has long been recognized due to their ability to transfer important cellular cargoes such as DNA,mRNA,miRNAs,and proteins to target cells.Compelling evidence supports the role of EVs in the horizontal transfer of cellular material which has the potential to influence normal cellular physiology and promote various disease states.Of the different types ofEVs,exosomes have garnered much attention in the past decade due to their abundance in various biological fluids and ability to affect multiple organ systems.The main focus of this review will be on cancer and how cancer-derived exosomes are important mediators of metastasis,angiogenesis,immune modulation,and the tumor macro-/microenvironment.We will also discuss exosomes as potential biomarkers for cancers due to their abundance in biological fluids,ease of uptake,and cellular content.Exosome use in diagnosis,prognosis,and in establishing treatment regimens has enormous potential to revolutionize patient care.
机标关键词：cellular materialmultiple organtarget cellstransfer of
分类号：Q25(细胞生理学)
资助基金：This work was partly supported by Florida Department of Health Cancer Research Chair Funding,NIH fund-ing (CA150190)This work was partly supported by Florida Department of Health Cancer Research Chair Funding,NIH fund-ing (HL 70567 and CA78383)This work was partly supported by Florida Department of Health Cancer Research Chair Funding,NIH fund-ing (and Mayo Clinic Pancreatic Cancer SPORE P50 CA102701 Pilot Project) to DM and NCI training grant 1T32 CA148073 (to DM)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 386-394 )
英文信息