Hydrogen-enriched water eliminates fine particles from the lungs and blood by enhancing phagocytic activity
Jieun Choi
Eun Suk An
Young-Hwan Ban
Da Woom Seo
Tae-Su Kim
Sung-Pyo Lee
You Lin
Ehn-Kyoung Choi
Yun-Bae Kim
摘要：Particulate matters (PM) are one of the major body burdens leading to diseases.We investigated the capacities of a hydrogen-enriched water (HW) eliminating carbon nanoparticles (CNP) and carbon microparticles (CMP) from the lungs and blood,respectively.In CNP-elimination test,rats were orally administered with purified water (PW) or HW (10 or 30 mL/kg/day) for 10 weeks.At the time point of 4 weeks,the rats were challenged with intratracheal instillation of CNP (4 mg).CNP accumulated in the airways and alveoli,and induced inflammatory lesions.Such pneumoconiosis was markedly improved by feeding HW,while PW was ineffective.CNP-induced pneumoconiosis caused systemic hematological alterations,decreasing major inflammatory cells,but markedly increasing eosinophils,indicative of an allergic reaction,which were attenuated by treatment with HW.Such PM-eliminating and antiallergic effects of HW reduced body burden as confirmed from the facilitated recovery of body and lung weights.In CMP-clearance test,mice were orally administered with PW or HW for 7 days,and intravenously injected with CMP (300 mg/kg).CMP was rapidly eliminated from the blood in HW-fed mice.Indeed,the phagocytic indices increased to 3.5 and 6.7 folds at 10 and 30 mL/kg of HW,in comparison with a negligible effect of PW.As a mechanism study,only HW significantly inhibited lipid peroxidation in vitro Fenton reaction-mediated.OH-generating system.Collectively,the results indicate that HW not only effectively eliminated PM from the lungs and blood by enhancing phagocytic activity,but also attenuated the lung injuries by inhibiting lipid peroxidation.
机标关键词：orally administeredlipid peroxidationinflammatory cellsmechanism studypurified watertime pointin vitro
分类号：R122.2(环境医学、环境卫生)
论文发表日期：2017-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 503-511 )
英文信息