Oxidized phospholipids and lipoprotein-associated phospholipase A2 as important determinants of Lp(a) functionality and pathophysiological role
Alexandros D.Tselepis
摘要：Lipoprotein(a) [Lp(a)] is composed of a low density lipoprotein (LDL)-like particle to which apolipoprotein (a)[apo(a)] is linked by a single disulfide bridge.Lp(a) is considered a causal risk factor for ischemic cardiovascular disease (CVD) and calcific aortic valve stenosis (CAVS).The evidence for a causal role of Lp(a) in CVD and CAVS is based on data from large epidemiological databases,mendelian randomization studies,and genome-wide association studies.Despite the well-established role of Lp(a) as a causal risk factor for CVD and CAVS,the underlying mechanisms are not well understood.A key role in the Lp(a) functionality may be played by its oxidized phospholipids (OxPL) content.Importantly,most of circulating OxPL are associated with Lp(a);however,the underlying mechanisms leading to this preferential sequestration of OxPL on Lp(a) over the other lipoproteins,are mostly unknown.Several studies support the hypothesis that the risk of Lp(a) is primarily driven by its OxPL content.An important role in Lp(a) functionality may be played by the lipoprotein-associated phospholipase A2 (Lp-PLA2),an enzyme that catalyzes the degradation of OxPL and is bound to plasma lipoproteins including Lp(a).The present review article discusses new data on the pathophysiological role of Lp(a) and particularly focuses on the functional role of OxPL and Lp-PLA2 associated with Lp(a).
机标关键词：
分类号：R589.2(内分泌腺疾病及代谢病)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 13-22 )
英文信息