Re-evaluating the role of epithelial-mesenchymal-transition in cancer progression
Andrew Sulaiman
Zemin Yao
Lisheng Wang
摘要：Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are essential for embryonic development and also important in cancer progression.In a conventional model,epithelial-like cancer cells transit to mesenchymal-like tumor cells with great motility via EMT transcription factors;these mesenchymallike cells migrate through the circulation system,relocate to a suitable site and then convert back to an epithelial-like phenotype to regenerate the tumor.However,recent findings challenge this conventional model and support the existence of a stable hybrid epitheliai/mesenchymal (E/M) tumor population.Hybrid E/M tumor cells exhibit both epithelial and mesenchymal properties,possess great metastatic and tumorigenic capacity and are associated with poorer patient prognosis.The hybrid E/M model and associated regulatory networks represent a conceptual change regarding tumor metastasis and organ colonization.It may lead to the development of novel treatment strategies to ultimately stop cancer progression and improve disease-free survival.
机标关键词：
分类号：R737.9(泌尿生殖器肿瘤)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 81-90 )
英文信息