Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea
Sang-Yong Eom
Dong-Hyuk Yim
Dae-Hoon Kim
Hyo-Yung Yun
Young-Jin Song
Sei-Jin Youn
Taisun Hyun
Joo-Seung Park
Byung Sik Kim
Yong-Dae Kim
Heon Kim
摘要：There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations,but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin Dpathway.The effects of vitamin D intake,vitamin D related genetic polymorphisms,and their association with the incidence of gastric cancer were investigated in a hospital case-control study,including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex.Correlations between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of subjects.No statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls,nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate analyses.Vitamin D intake significantly correlated with the circulating 2 5-hydroxyvitamin D levels,but not with the active form of the vitamin,1,25-dihydroxyvitamin D.There were no statistically significant interactions between vitamin D intake,and VDR or TXNIP polymorphisms.This study suggests that dietary vitamin D intake is not associated with gastric cancer risk,and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.
机标关键词：
分类号：R735.2(消化系肿瘤)
资助基金：the National Research Foundation of Korea Grant,funded by the Korean Government (Ministry of Education)the National Research Foundation of Korea Grant,funded by the Korean Government (Science and Technology) (NRF-355-2010-1-E00026 and 2012R1-A1A2044765)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：7( 257-263 )
英文信息