Clinical features of multiple myeloma patients with isolated extramedullary relapse
Xiaoyan Qu
Lijuan Chen
Tian Tian
Limin Duan
Ruinan Lu
Hua Lu
Hanxin Wu
Jianyong Li
摘要：This study sought to analyze the clinical features and prognosis of multiple myeloma with isolated extramedullary relapse and with the absence of systemic progression.The clinical features and outcome were retrospectively analyzed in six multiple myeloma patients.These patients had secretory multiple myeloma at diagnosis.Whenrelapsed,the dissociation between medullary and extramedullary response was detected.The serum or urine monoclonal component was extremely low or absent.The plasma cells in bone marrow were ＜ 5％.All patients received new targeted therapies (thalidomide or bortezomib) before extramedullary relapse.It is difficult to achieve second remission for them.Even in those showing response,the duration of response was extremely short.The median of overall survival from diagnosis and from extramedullary relapse was 19 months and 6 months,respectively.The overall survival was significantly shorter compared to the patients without extramedullary involvement (84 months,P =0.001).These patients exhibited a special and rare relapse pattern.Patients with this relapse pattern were resistant to current therapies,including novel targeted agents and associated with poor prognosis.
机标关键词：
分类号：R73(肿瘤学)
资助基金：Foundation of National Natural Science Foundation of China(81241074)Foundation of National Natural Science Foundation of China(81071946 and 81302040)Natural Science Foundation of Jiangsu Province(BK2012485)Jiangsu Province's Medical Elite Program(RC201148)a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions,the Program for Development of Innovative Research Team in the First Affiliated Hospital of NJMU,Clinical Research Program from Health Ministry of China(Key project 2010 to 2012)Scientific Research Program for Public Interests from the Health Ministry of China(201202017)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：6( 264-269 )
英文信息