Pathway-based analysis of genome-wide association study of circadian phenotypes
Didi Zhu
Jiamin Yuan
Rui Zhu
Yao Wang
Zhiyong Qian
Jiangang Zou
摘要：Sleepiness affects normal social life,which attracts more and more attention.Circadian phenotypes contribute to obvious individual differences in susceptibility to sleepiness.We aimed to identify candidate single nucleotide polymorphisms (SNPs) which may cause circadian phenotypes,elucidate the potential mechanisms,and generate corresponding SNP-gene-pathways.A genome-wide association studies (GWAS) dataset of circadian phenotypes was utilized in the study.Then,the Identify Candidate Causal SNPs and Pathways analysis was employed to the GWAS dataset after quality control filters.Furthermore,genotype-phenotype association analysis was performed with HapMap database.Four SNPs in three different genes were determined to correlate with usual weekday bedtime,totally providing seven hypothetical mechanisms.Eleven SNPs in six genes were identified to correlate with usual weekday sleep duration,which provided six hypothetical pathways.Our results demonstrated that fifteen candidate SNPs in eight genes played vital roles in six hypothetical pathways implicated in usual weekday bedtime and six potential pathways involved in usual weekday sleep duration.
机标关键词：
分类号：R737.9(泌尿生殖器肿瘤)
资助基金：the National Natural Science Foundation of China (No.81470457 and No.81700297)
论文发表日期：2018-01-01
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 361-370 )
英文信息